A Universal Isocyanide for Diverse Heterocycle Syntheses

A Universal Isocyanide for Diverse Heterocycle Syntheses

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

New Ligands for Nickel Catalysis from Diverse Pharmaceutical Heterocycle Libraries

Ligands are essential for controlling the reactivity and selectivity of reactions catalysed by transition metals. Access to large phosphine ligand libraries has become an essential tool for the application of metal-catalysed reactions industrially, but these existing libraries are not well suited to new catalytic methods based on non-precious metals (for example, Ni, Cu and Fe). The development...

Mani and shapur a universal faith for e universal kingdom

SELENIUM HETEROCYCLE XL II [1]. SYNTHESES OF SUBSTITUTED THIAZOLO, SELENAZOLO AND 1,2,3-SELENADIAZOLOINDOLES

Reaction of compound 1 with thiobenzarnide or substituted selenobenzamides afforded substituted pyrrolobenzothiazole or selenazoles (2) respectively. Selenium dioxide oxidation of the semicarbazone 4 with selenium dioxide gave 6- benzenesulfonyl- 4,5-dihydro-pynolo [3,2-el benzoselenadiazole (5).

The [3 + 3]-Cycloaddition Alternative for Heterocycle Syntheses: Catalytically Generated Metalloenolcarbenes as Dipolar Adducts

The combination of two or more unsaturated structural units to form cyclic organic compounds is commonly referred to as cycloaddition, and the combination of two unsaturated structural units that forms a six-membered ring is formally either a [5 + 1]-, [4 + 2]-, [2 + 2 + 2]-, or [3 + 3]-cycloaddition. Occurring as concerted or stepwise processes, cycloaddition reactions are among the most usefu...